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#31 K Wave

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Posted 15 July 2020 - 02:56 PM

K-wave

 

you are also the guy who said repeatedly that I was wrong and that "this whole thing would be over by July "

Not quite correct. I said the 7 day MA would peak in July in the surge states, and it would be mostly over by Mid-August.

 

So yes, worst over in July.

 

Will post the curves this evening after the daily update, and you will see that AZ, CA, TX FL all have flattened or now falling 7 day MA...as predicted ahead of time...and pretty much right on schedule...

 

On the overall death curve for the entire country, we had slight blip up last week, and it is now back into decline....on its way to looking like Sweden and New York over coming weeks.


The strength of Government lies in the people's ignorance, and the Government knows this, and will therefore always oppose true enlightenment. - Leo Tolstoy

 

 


#32 Dex

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Posted 15 July 2020 - 03:04 PM

 

Vaccination trials company Moderno has good trials effective.

 Although Fauci says vaccination will be  only 50-70% effective. 

There will NEVER be a vaccine...it's all a sham.

 

Those who think, hope or pray otherwise didn't do well in their biology class...it's all propaganda.

 

Fib

 

Fib, nice to see you post.  We could use more of your sanity.

 

I agree, there may never be a vaccine.  I think the best we can hope for is some sort of herd immunity or something that boosts the immunity to fight the virus and weaken the negative effects.


Edited by Dex, 15 July 2020 - 03:07 PM.

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#33 12SPX

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Posted 15 July 2020 - 03:13 PM

See again Fauci saying at the close there will be a vaccine this year.  What do we do with that, you would think that if its a complete lie someone would say something.



#34 pdx5

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Posted 15 July 2020 - 03:18 PM

See again Fauci saying at the close there will be a vaccine this year.  What do we do with that, you would think that if its a complete lie someone would say something.

You can NOT call ANY future predictions as lies. The future has not arrived here yet.

I am predicting SPX will be at 10,000 on April 15th 2023. No way to prove it is a lie. 2023 is not here yet LOL.


Edited by pdx5, 15 July 2020 - 03:25 PM.

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#35 traderx

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Posted 15 July 2020 - 03:24 PM

si ,right



#36 Dex

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Posted 15 July 2020 - 03:34 PM

See again Fauci saying at the close there will be a vaccine this year.  What do we do with that, you would think that if its a complete lie someone would say something.

 

Saying that doesn't mean much in itself.  The general public's thought is that a vaccine would be something like that of polio - eradicate it. 

https://www.medscape...cle/930986#vp_2

 

Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center.

A successful vaccine for prevention of SARS-CoV-2 infection will probably need to incorporate T-cell epitopes to induce a long-term memory T-cell immune response to the virus, Mehrdad Matloubian, MD, PhD, predicted at the virtual edition of the American College of Rheumatology's 2020 State-of-the-Art Clinical Symposium.

Vaccine-induced neutralizing antibodies may not be sufficient to reliably provide sustained protection against infection. In mouse studies, T-cell immunity has protected against reinfection with the novel coronaviruses. And in some but not all studies of patients infected with the SARS virus, which shares 80% genetic overlap with the SARS-CoV-2 virus responsible for the COVID-19 pandemic, neutralizing antibodies have waned over time.

"In one study, 20 of 26 patients with SARS had lost their antibody response by 6 years post infection. And they had no B-cell immunity against the SARS antigens. The good news is they did have T-cell memory against SARS virus, and people with more severe disease tended to have more T-cell memory against SARS. All of this has really important implications for vaccine development," observed Dr. Matloubian, a rheumatologist at the University of California, San Francisco.

 

Dr. Matloubian is among those who are convinced that the ongoing massive global accelerated effort to develop a safe and effective vaccine affords the best opportunity to gain the upper hand in the COVID-19 pandemic. A large array of vaccines are in development.

A key safety concern to watch for in the coming months is whether a vaccine candidate is able to sidestep the issue of antibody-dependent enhancement, whereby prior infection with a non-SARS coronavirus, such as those that cause the common cold, might result in creation of rogue subneutralizing coronavirus antibodies in response to vaccination. There is concern that these nonneutralizing antibodies could facilitate entry of the virus into monocytes and other cells lacking the ACE2 receptor, its usual portal of entry. This in turn could trigger expanded viral replication, a hyperinflammatory response, and viral spread to sites beyond the lung, such as the heart or kidneys.

Little Optimism About Antivirals' Impact

Dr. Matloubian predicted that antiviral medications, including the much-ballyhooed remdesivir, are unlikely to be a game changer in the COVID-19 pandemic. That's because most patients who become symptomatic don't do so until at least 2 days post infection. By that point, their viral load has already peaked and is waning and the B- and T-cell immune responses are starting to gear up.

"Timing seems to be everything when it comes to treatment with antivirals," he observed. "The virus titer is usually declining by the time people present with severe COVID-19, suggesting that at this time antiviral therapy might be of little use to change the course of the disease, especially if it's mainly immune-mediated by then. Even with influenza virus, there's a really short window where Tamiflu [oseltamivir] is effective. It's going to be the same case for antivirals used for treatment of COVID-19."

He noted that in a placebo-controlled, randomized trial of remdesivir in 236 Chinese patients with severe COVID-19, intravenous remdesivir wasn't associated with a significantly shorter time to clinical improvement, although there was a trend in that direction in the subgroup with symptom duration of 10 days or less at initiation of treatment.

A National Institutes of Health press release announcing that remdesivir had a positive impact on duration of hospitalization in a separate randomized trial drew enormous attention from a public desperate for good news. However, the full study has yet to be published, and it's unclear when during the disease course the antiviral agent was started.

"We need a blockbuster antiviral that's oral, highly effective, and doesn't have any side effects to be used in prophylaxis of health care workers and for people who are exposed by family members being infected. And so far there is no such thing, even on the horizon," according to the rheumatologist.

 

Fellow panelist Jinoos Yazdany, MD, concurred.

 

"As we talk to experts around the country, it seems like there isn't very much optimism about such a blockbuster drug. Most people are actually putting their hope in a vaccine," said Dr. Yazdany, professor of medicine at the University of California, San Francisco, and chief of rheumatology at San Francisco General Hospital.

 

Another research priority is identification of biomarkers in blood or bronchoalveolar lavage fluid to identify early on the subgroup of infected patients who are likely to crash and develop severe disease. That would permit a targeted approach to inhibition of the inflammatory pathways contributing to development of acute respiratory distress syndrome before this full-blown cytokine storm-like syndrome can occur. There is great interest in trying to achieve this by repurposing many biologic agents widely used by rheumatologists, including the interleukin-1 blocker anakinra (Kineret) and the IL-6 blocker tocilizumab (Actemra).

 

Dr. Matloubian reported having no financial conflicts of interest regarding his presentation.


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#37 Dex

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Posted 15 July 2020 - 03:36 PM

https://www.statnews...ng-their-power/

 

 

“We all recognize that flu vaccine, in a year when it’s efficacious, you have what, 50% protection? And in a year when it’s poor you have 30% or less than that — and still we use that,” said Marie-Paule Kieny, who is chairing a committee advising the French government on vaccines to prevent Covid-19.


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#38 12SPX

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Posted 16 July 2020 - 07:29 AM

 

See again Fauci saying at the close there will be a vaccine this year.  What do we do with that, you would think that if its a complete lie someone would say something.

You can NOT call ANY future predictions as lies. The future has not arrived here yet.

I am predicting SPX will be at 10,000 on April 15th 2023. No way to prove it is a lie. 2023 is not here yet LOL.

 

No no you misunderstand me.  Fib said that Corona is more related to a cold virus so there can never be a vaccine.  What I'm trying to understand is why do they keep saying there will be one then if its so impossible to get one,,,,,keep the hope alive....... Wouldn't that be a major disappoint for everyone if there isn't one by fall?



#39 pdx5

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Posted 16 July 2020 - 09:00 AM

 

No no you misunderstand me.  Fib said that Corona is more related to a cold virus so there can never be a vaccine.  What I'm trying to understand is why do they keep saying there will be one then if its so impossible to get one,,,,,keep the hope alive....... Wouldn't that be a major disappoint for everyone if there isn't one by fall?

 

My expertise is in designing industrial machines, not vaccines. So my opinion on vaccines and $4 might buy you a cup of coffee at Starbux.

 

But it is possible that the covid-19 virus is different enough from the common cold virus so vaccine is possible. Keep in mind no vaccine is fool-proof. If virus exposure is large enough quantity, it can overwhelm any resistance acquired from a vaccine. 


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#40 fib_1618

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Posted 16 July 2020 - 12:25 PM

 

 

See again Fauci saying at the close there will be a vaccine this year.  What do we do with that, you would think that if its a complete lie someone would say something.

You can NOT call ANY future predictions as lies. The future has not arrived here yet.

I am predicting SPX will be at 10,000 on April 15th 2023. No way to prove it is a lie. 2023 is not here yet LOL.

 

No no you misunderstand me.  Fib said that Corona is more related to a cold virus so there can never be a vaccine.  What I'm trying to understand is why do they keep saying there will be one then if its so impossible to get one,,,,,keep the hope alive....... Wouldn't that be a major disappoint for everyone if there isn't one by fall?

 

 

Although I can't find the quote directly, and for the sake of clarity, there have been at least two Corona type virus' (it's called that because of its structural extenders) that have had the symptoms of the what many would think is just the common cold. COVID-19, overall, has more symptoms of just sneezing or coughing and having a runny nose, so this form is more closely related to that of the myriad of forms of influenza of which include Corona types. It should also be noted that the death rate with this virus is nowhere near those of other proclaimed "pandemics" of the past like that of 1957's Asian Flu, 1968's Hong Kong Flu and, of course, the Spanish Flu of 1918 (which wasn't Spanish at all but came about with the huge number of dead from World War 1) where we STILL don't have a vaccines for! The only thing people could do in each of those cases was to get out in the sun (and it's vitamin D properties) and just practicing good hygiene which did include the wearing of masks in close spaces.

 

And, to be sure, that there are other contagions that people can get no matter how we protect ourselves like polio (virus), tuberculous and plague (bacteria), and even malaria (parasitic).

 

But more importantly in all of this, no one lived in fear of getting sick and dying (though they were concerned), that we didn't shut down whole economies, and we all accepted the fact that this is something we all have to live with on this tiny ball in the vastness of the universe. I believe that all life on this planet has a function...some are good, some are bad.

 

It is what it is.

 

Fib


Edited by fib_1618, 16 July 2020 - 12:27 PM.

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