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Skin cancer: Half now survive advanced melanoma


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#1 Rogerdodger

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Posted 28 September 2019 - 09:45 AM

Skin cancer: Half now survive advanced melanoma

Sept. 28, 2019
There were 945 patients in the trial, a third were given nivolumab, a third were given ipilimumab and a third were given both.
Doctors then looked at the five-year survival rate - the proportion of patients still alive after five years.
The results showed:
    26% were still alive on ipilimumab alone
    44% were still alive on nivolumab alone
    and 52% were still alive when given both.

Ipilimumab and nivolumab both stop some cancers from hiding and allow the immune system to attack.
They interrupt the chemical signals that cancers use to put the brakes on the immune system.
Nivolumab blocks the off-switch on white blood cells called PD-1. Ipilimumab blocks a similar switch called CTLA-4.
It is described as taking the brakes off the immune system.
"By giving these drugs together you are effectively taking two brakes off the immune system rather than one so that the immune system is able to recognise tumours it wasn't previously recognising and react to that and destroy them," Prof Larkin said.
Earlier results from this trial led to these drugs being made available around the world - including on the UK's National Health Service.
The decision to approve the drugs for melanoma was one of the fastest in NHS history.
And they are also being used in other cancers such as lung and kidney.



#2 hhh

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Posted 28 September 2019 - 10:04 AM

I would use cannabis oil. It cured a dark tumour-like blob on my cat's nose in a few weeks and a friend's skin tumour as well.



#3 Rogerdodger

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Posted 18 November 2019 - 07:26 AM

So far Cannabis oil is Scientifically proven to be as effective as placebo oil... Or Blue Emu oil, Snake oil and even WD-40! 

"Spray or rub on WD-40 to loosen up painful, stiff, arthritic joints; kind of similar to the Tin Man in the “The Wizard of Oz.”....

 

So far, messages of CBD’s purported health benefits come from people trying to sell CBD products — not from scientists, says Margaret Haney, a neurobiologist who directs the Marijuana Research Laboratory at Columbia University. A gaping chasm separates the surging CBD market and the scientific evidence backing it. While there are reasons to be excited about CBD, the science just isn’t there yet.

 



#4 Rogerdodger

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Posted 18 November 2019 - 07:55 AM

On the other hand...

 

Cannabis has long been known to limit or prevent nausea and vomiting from a variety of causes. This has led to extensive investigations that have revealed an important role for cannabinoids and their receptors in the regulation of nausea and emesis. With the discovery of the endocannabinoid system, novel ways to regulate both nausea and vomiting have been discovered that involve the production of endogenous cannabinoids acting centrally.[17] The plant cannabis has been used in clinics for centuries, and has been known to be beneficial in a variety of gastrointestinal diseases, such as emesis, diarrhea, inflammatory bowel disease and intestinal pain. Moreover, modulation of the endogenous cannabinoid system in the gastrointestinal tract may provide a useful therapeutic target for gastrointestinal disorders.[18] While some GI disorders may be controlled by diet and pharmaceutical medications, others are poorly moderated by conventional treatments. Symptoms of GI disorders often include cramping, abdominal pain, inflammation of the lining of the large and/or small intestine, chronic diarrhea, rectal bleeding and weight loss. Patients with these disorders frequently report using cannabis therapeutically.[19]

In a 2012 animal study, cannabichromene was shown to normalize gastrointestinal hypermotility without reducing the transit time. The study notes that this result is of potential clinical interest, as the only drugs available for intestinal dysmotility are often associated with constipation.[20]

https://en.wikipedia...udo-obstruction



#5 hhh

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Posted 18 November 2019 - 08:05 AM

It's the THC that kills cancer, not the CBD, and it's clinically proven.