You guys might also want to do some research into regular old niacin B3 (Nicotinic Acid version).
There is an extremely strong correlation to levels of NAD+ in the system to Covid severity, as Covid severely depletes it.
It is speculated that since kids have very high levels to starts with, this is the main reason they essentially do not get sick from it. (I can verify that with my own kids, who have been exposed countless times, and only had very minor symptoms once.)
There has also been a ton of anti-aging work looking at NAD+ as a prime suspect.
Nicotinic Acid is great pre-cursor to NAD+, and can actually restore NAD+ levels in both sick and healthy folks.
Niacin Cures Systemic NAD + Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy
Here, we report systemic NAD+ deficiency in adult-onset mitochondrial myopathy patients. We administered an increasing dose of NAD+-booster niacin, a vitamin B3 form (to 750-1,000 mg/day; clinicaltrials.govNCT03973203) for patients and their matched controls for 10 or 4 months, respectively. Blood NAD+ increased in all subjects, up to 8-fold, and muscle NAD+ of patients reached the level of their controls. Some patients showed anemia tendency, while muscle strength and mitochondrial biogenesis increased in all subjects. In patients, muscle metabolome shifted toward controls and liver fat decreased even 50%.
And they also been having some success giving Niacin and Selenium to Long Covid folks, again targeting NAD+ levels.
The Team of Doctors and Biohackers Who Seem to Be Successfully Treating “Long Covid”
Simply, their theory is that COVID19 causes NAD+ depletion, some people with vitamin deficiencies, existing NAD+ depletion or genetic deficits in energy metabolism have long term NAD+ dysfunction. The body tries to make up for low NAD+ by feeding in tryptophan, which is the precursor for serotonin, causing low serotonin. Mast cells are activated locally to release serotonin instead, leading to histamine release and mast cell activation issues. Neurological effects are due to low serotonin and NAD+, which also effects the microbiome and general homoeostasis. Energy disruptions are specific to high metabolically active tissues such as the heart and brain. This is further complexed with disruption of the gut-immune axis, mobilization of bacteria, secondary infections - both bacterial and reactivation of dormant neurotrophic viruses.
The group treating this mechanism utilizes:
Nicotinic acid aka Niacin (most important and not nicotinamide or other forms) — 100mg
Vitamin C aka Ascorbic Acid — 1500mg
Vitamin D — 3000iu
Zinc — 15mg
Selenium — 50mcg
Quercetin — 500mg
With the reasonable likelihood of "vaccine escaped" variant coming our way fairly soon....might not be a bad idea to pump up your declining levels of NAD+.
Note with Niacin...liver toxicity has been seen at a dose around 3gr (3000 mg)...so more is not necessarily better.
And I would advise against slow or sustained release version for long term use, as toxicity has been seen at much lower levels, due to there being 2 different pathways that Niacin can use in the Body.
The instant release version that causes the flushing quickly uses up the bandwidth on the more dangerous path to the liver, and the vast majority goes down the safer path.
With the Slow or Sustained release version, due to the trickle effect, about 80% of the dose goes down the more dangerous pathway to the liver. Toxicty with Sustained release has been seen at dose as low as 500mg when used for many years.
Edited by K Wave, 09 September 2021 - 08:51 AM.